I have to get up regularly to get some feeling back in the legs and get the movement back in my dodgy knee. Aisle seat is the only option.
A middle seat on a long haul flight is grounds for immediate suicide as far as I am concerned.
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It only really bothers me when I am doing it all the time. I do hate it, but its something you just have to endure. Give me an aisle seat and leave the **** alone and I can cope. When people start ****ing with me they are just asking for trouble, particularly if I am into 6 or 7 hours without a fag.