My advice for anyone looking for a new car is simple nowadays. Buy the car you like, unless the car you like is a Renault, Citroen or Nissan. No one, except those three bandits, makes a bad car any more. Obviously forget diesel. I'd recommend going hybrid, particularly for P11D efficiency.
Do you really mean 'estate'? It's all about the SUV these days.
I have a lot to do with Lexus and therefore I'm biased, but in your position I'd look carefully at the RX450h.